Clofutriben

DB21636InvestigationalSmall molecule

Clofutriben is a small molecule drug. Clofutriben is under investigation in clinical trial NCT05307328 (SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome). Clofutriben has a monoisotopic molecular weight of...

Mechanism: Pharmacologically active on 11-beta-hydroxysteroid dehydrogenase 1
Curator reviewed
Formula / weight: C₁₉H₁₆ClF₃N₄O₂ · 424.81 g/mol (avg)
Code names: AS-2473662 · ASP-3662 · HDD-1697 · SPI-62

Resolves to

Compound

UNII4L1TY1U5VCCAS1204178-50-6ChEMBLCHEMBL5314513ChEBI759217PubChem44598960

Structure

InChIKeyCMQOKZCYVZFZLZ-UHFFFAOYSA-NSMILESCN1C(=NN=C1C(C)(C)OC1=C(F)C=C(Cl)C=C1F)C1=CC=C(C=C1F)C(N)=O

Targets

P28845HSD11B1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

10Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Clofutriben, and which of those have an active Phase 3 trial?

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