11-beta-hydroxysteroid dehydrogenase 1

BE0000329ProteinHumansHSD11B1

Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:10497248, PubMed:12460758, PubMed:14973125, PubMed:15152005, PubMed:15280030, PubMed:17593962, PubMed:21453287, PubMed:23685396, PubMed:27927697, PubMed:30902677). It is acted on by 39 drugs in DrugBank.

Gene name
HSD11B1
UniProtKB entry
P28845Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
292 residues · 32,401 Da
Also known as
1.1.1.146 · 11-beta-HSD1 · 11-DH · 7-oxosteroid reductase · Corticosteroid 11-beta-dehydrogenase isozyme 1

Resolves to

Protein
UniProtP28845UniProt nameDHI1_HUMAN
Gene
HGNCHGNC:5208NCBI Gene3290GenBank179475GeneCardsHSD11B1
Pharmacology
IUPHAR/GtoPdb2763KEGGhsa:3290
Structure
PDB1XU7PDB1XU9PDB2BEL
Drugs

What you can answer from here — as of September 03, 2024

39DrugsApproved to experimental, with action, bond type and pharmacological action
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11Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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86+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 11-beta-hydroxysteroid dehydrogenase 1, how selective are they, and which programs against it are still in active trials?

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