Setidegrasib

DB21670InvestigationalSmall molecule

Setidegrasib is a small molecule drug. The usage of the INN stem '-rasib' in the name indicates that Setidegrasib is a Ras protein inhibitor. Setidegrasib has a monoisotopic molecular weight...

Mechanism: Pharmacologically active on GTPase KRas and von Hippel-Lindau disease tumor suppressor
Curator reviewed
Formula / weight: C₆₀H₆₅FN₁₂O₇S · 1117.32 g/mol (avg)
Code names: ASP3082

Resolves to

Compound

UNII3NQ4ME292XCAS2821793-99-9

Structure

InChIKeyXXWMEQMGQNHRAF-WFJRNIGCSA-NSMILES

[H][C@]12CN(C3=C4C=C(C5CC5)C(=C(OCC5=CC=C(C=C5)C5=CN(N=N5)[C@@H](C(C)C)C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](CO)C5=CC=C(C=C5)C5=C(C)N=CS5)C4=NC(OC4CCOCC4)=N3)C3=C4C=NNC4=CC(F)=C3C)[C@]([H])(CN1)C2

Targets

P01116KRASP40337VHL

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Setidegrasib, and which of those have an active Phase 3 trial?

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