Olomorasib

DB21697InvestigationalSmall molecule

Olomorasib is a small molecule drug. The usage of the INN stem '-rasib' in the name indicates that Olomorasib is a Ras protein inhibitor. Olomorasib is under investigation in clinical... Olomorasib is under investigation in clinical trial NCT06890598 (Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer).

Mechanism: Pharmacologically active on GTPase KRas
Curator reviewed
Formula / weight: C₂₅H₁₉ClF₂N₄O₃S · 528.96 g/mol (avg)
Code names: LY-3537982

Resolves to

Compound

UNIIC2VJ83PSN7CAS2771246-13-8ChEMBLCHEMBL6068410

Structure

InChIKeyOZUPICRWMLEFCS-LBPRGKRZSA-NSMILES[H][C@]12CN(CCN1C(=O)C1=C(OCC2)C(Cl)=C(C(F)=C1)C1=C2C(SC(N)=C2C#N)=C(F)C=C1)C(=O)C=C

Targets

P01116KRAS

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

10Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Olomorasib, and which of those have an active Phase 3 trial?

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