Casdatifan

DB21701InvestigationalSmall molecule

Casdatifan is a small molecule drug. The usage of the INN stem '-tifan' in the name indicates that Casdatifan is a hypoxia inducible factor (HIF)-2alpha (HIF-2a) inhibitor. Casdatifan is under... Casdatifan is under investigation in clinical trial NCT07000149 (A Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCC).

Mechanism: Pharmacologically active on Endothelial PAS domain-containing protein 1
Curator reviewed
Formula / weight: C₂₁H₁₇F₄NO₃S · 439.42 g/mol (avg)
Code names: AB521

Resolves to

Compound

UNIIDP73UWL6LECAS2709069-30-5

Structure

InChIKeyKHBHHNNBNHHGPE-QCCZFBHPSA-NSMILES[H][C@@]1(C[C@H](F)[C@H](F)C2=C1C(=CC(F)=C2)C#N)C1=C2C[C@@H](F)[C@@H](O)C2=C(C=C1)S(C)(=O)=O

Targets

Q99814EPAS1

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

11Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Casdatifan, and which of those have an active Phase 3 trial?

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