Endothelial PAS domain-containing protein 1

BE0009679ProteinHumansEPAS1

Transcription factor involved in the induction of oxygen regulated genes. It is acted on by 5 drugs in DrugBank.

Gene name
EPAS1
UniProtKB entry
Q99814Swiss-Prot
Cellular location
Nucleus
Residues / weight
870 residues · 96,458 Da
Also known as
Basic-helix-loop-helix-PAS protein MOP2 · BHLHE73 · Class E basic helix-loop-helix protein 73 · EPAS-1 · HIF-1-alpha-like factor

Resolves to

Protein
UniProtQ99814UniProt nameEPAS1_HUMAN
Gene
HGNCHGNC:3374NCBI Gene2034GeneCardsEPAS1
Pharmacology
IUPHAR/GtoPdb3148KEGGhsa:2034
Structure
PDB1P97PDB2A24PDB3F1N
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Endothelial PAS domain-containing protein 1, how selective are they, and which programs against it are still in active trials?

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