Istisociclib

DB21703InvestigationalSmall molecule

Istisociclib is a small molecule drug. The usage of the INN stem '-ciclib' in the name indicates that Istisociclib is a cyclin dependant kinase inhibitor. Istisociclib is under investigation in... Istisociclib is under investigation in clinical trial NCT04718675 (A Study of KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC)).

Mechanism: Pharmacologically active on Cyclin-dependent kinase 9
Curator reviewed
Formula / weight: C₁₆H₂₅N₅ · 287.411 g/mol (avg)
Code names: KB-00130742 · KB-0742 · KB-130742 · UB-18422

Resolves to

Compound

UNIIF7J6KSY5I8CAS2416873-83-9ChEMBLCHEMBL5199065ChEBI759068PubChem146502834

Structure

InChIKeyVYKCLMALANGCDF-STQMWFEESA-NSMILESCCC(CC)C1=NC2=CC=NN2C(N[C@H]2CC[C@H](N)C2)=C1

Targets

P50750CDK9

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Istisociclib, and which of those have an active Phase 3 trial?

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