Cyclin-dependent kinase 9

BE0002207ProteinHumansCDK9

Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094, PubMed:29335245). It is acted on by 19 drugs in DrugBank.

Gene name
CDK9
UniProtKB entry
P50750Swiss-Prot
Cellular location
Nucleus
Residues / weight
372 residues · 42,777 Da
Also known as
2.7.11.22 · 2.7.11.23 · C-2K · CDC2L4 · Cell division cycle 2-like protein kinase 4

Resolves to

Protein
UniProtP50750UniProt nameCDK9_HUMAN
Gene
HGNCHGNC:1780NCBI Gene1025GenBank493130GeneCardsCDK9
Pharmacology
IUPHAR/GtoPdb1981KEGGhsa:1025
Structure
PDB3BLHPDB3BLQPDB3BLR
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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114+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 9, how selective are they, and which programs against it are still in active trials?

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