Fosrolapitant

DB21723InvestigationalSmall molecule

Fosrolapitant is a small molecule drug. The usage of the INN stem '-pitant' in the name indicates that Fosrolapitant is a neurokinin NK1 (substance P) receptor antagonist. Fosrolapitant has a... Fosrolapitant has a monoisotopic molecular weight of 654.16 Da.

Mechanism: Pharmacologically active on Substance-P receptor
Curator reviewed
Formula / weight: C₂₇H₂₉F₆N₂O₈P · 654.499 g/mol (avg)

Resolves to

Compound

UNIIM5QGY92X8BCAS2573694-38-7ChEMBLCHEMBL6068054

Structure

InChIKeyPKXQGSOAMISYFP-LJXNEXSDSA-NSMILESC[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1C(=O)OCOP(O)(O)=O)C1=CC=CC=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F

Targets

P25103TACR1

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Fosrolapitant, and which of those have an active Phase 3 trial?

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