Substance-P receptor

BE0000384ProteinHumansTACR1

Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K (PubMed:1718267, PubMed:15452552). It is acted on by 36 drugs in DrugBank.

Gene name
TACR1
UniProtKB entry
P25103Swiss-Prot
Cellular location
Cell membrane
Residues / weight
407 residues · 46,251 Da
Also known as
NK-1 receptor · NK-1R · NK1R · SPR · TAC1R

Resolves to

Protein
UniProtP25103UniProt nameNK1R_HUMAN
Gene
HGNCHGNC:11526NCBI Gene6869GenBank8176544GeneCardsTACR1
Pharmacology
IUPHAR/GtoPdb360KEGGhsa:6869
Structure
PDB2KS9PDB2KSAPDB2KSB
Drugs

What you can answer from here — as of September 03, 2024

36DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
10Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
45GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
96+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Substance-P receptor, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In