Certociclib

DB21736InvestigationalSmall molecule

Certociclib is a small molecule drug. Certociclib is under investigation in clinical trial NCT05252416 ((VELA) Study of BLU-222 in Advanced Solid Tumors). Certociclib has a monoisotopic molecular weight of 365.14...

Mechanism: Pharmacologically active on Cyclin-dependent kinase 2
Curator reviewed
Formula / weight: C₁₅H₁₇F₂N₇O₂ · 365.345 g/mol (avg)
Code names: BLU-170298 · BLU-222 · CDK2 Inhibitor BLU-222

Resolves to

Compound

UNIIU93X72ED47CAS2888704-84-3ChEMBLCHEMBL6068424ChEBI760335PubChem168752082

Structure

InChIKeyIFJSYTKOMJJYNP-UHFFFAOYSA-NSMILESFC(F)OC1=CC(NC2=CN=C3C=NN(CC4CCOCC4)C3=N2)=NN1

Targets

P24941CDK2

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Certociclib, and which of those have an active Phase 3 trial?

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