Zeprumetostat

DB21740InvestigationalSmall molecule

Zeprumetostat is a small molecule drug. The usage of the INN stem '-metostat' in the name indicates that Zeprumetostat is a histone N-methyltransferase inhibitor. Zeprumetostat has a monoisotopic molecular weight...

Mechanism: Pharmacologically active on Histone-lysine N-methyltransferase EZH2
Curator reviewed
Formula / weight: C₃₂H₄₄N₄O₄ · 548.728 g/mol (avg)

Resolves to

Compound

UNIIXLJ9D8HE8YCAS2098545-98-1ChEMBLCHEMBL5939817ChEBI759871PubChem135332280

Structure

InChIKeyYLZVNQZYAYVUCW-UHFFFAOYSA-NSMILESCCN(C1CCOCC1)C1=C(CC)C(C(=O)NCC2=C(C)C=C(C)NC2=O)=C2C=C(CN3CCCCC3)OC2=C1

Targets

Q15910EZH2

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

12Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Zeprumetostat, and which of those have an active Phase 3 trial?

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