RGN6024

DB33059ExperimentalSmall molecule

RGN6024 is a Reglagene brain-penetrant tubulin destabilizer in preclinical development for glioblastoma and brain metastases. It received FDA orphan drug designation for glioblastoma in 2024 and has no approved use. RGN6024, also known as RGN-6024 or RGNi6024, is a synthetic small-molecule tubulin destabilizer from Reglagene.

Mechanism: Pharmacologically active on Tubulin beta chain
Curator reviewed
Formula / weight: C₁₈H₂₁N₅O₄S · 403.46 g/mol (avg)
Code names: RGN-6024 · RGNi6024

Resolves to

Compound

CAS3055038-20-2

Structure

InChIKeyOZQOKIPXKCUQMJ-UHFFFAOYSA-NSMILESCOC12CC(C1)(C2)C(=O)NC1=NC=C(OC2=CN=C(N=C2)N2CCOCC2)S1

Targets

P07437TUBB

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with RGN6024, and which of those have an active Phase 3 trial?

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