Trospium chlorideProduct ingredient for Trospium
- Name
- Trospium chloride
- Drug Entry
- Trospium
Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.1 An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination.1 Trospium is manufactured by Indevus Pharmaceutical Inc. and was granted FDA approval in 2007.2
- Accession Number
- DBSALT000883
- Structure
- Synonyms
- Not Available
- UNII
- 1E6682427E
- CAS Number
- 10405-02-4
- Weight
- Average: 427.97
Monoisotopic: 427.1914215 - Chemical Formula
- C25H30ClNO3
- InChI Key
- RVCSYOQWLPPAOA-QKYUOBHYSA-M
- InChI
- InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23+;
- IUPAC Name
- (1R,3S,5S)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8λ⁵-azaspiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ylium chloride
- SMILES
- [Cl-].[H][C@]12CC[C@]([H])(C[C@@]([H])(C1)OC(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1)[N+]21CCCC1
- External Links
- PubChem Compound
- 66524159
- ChemSpider
- 16740183
- BindingDB
- 50540489
- ChEBI
- 32270
- ChEMBL
- CHEMBL3084748
- Wikipedia
- Trospium_chloride
- Predicted Properties
Property Value Source Water Solubility 7.92e-05 mg/mL ALOGPS logP 0.55 ALOGPS logP -0.5 Chemaxon logS -6.7 ALOGPS pKa (Strongest Acidic) 11.05 Chemaxon pKa (Strongest Basic) -4.5 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 46.53 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 124.04 m3·mol-1 Chemaxon Polarizability 43.95 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon