Ketotifen fumarateProduct ingredient for Ketotifen

Show full entry for Ketotifen
Name
Ketotifen fumarate
Drug Entry
Ketotifen

Ketotifen is a benzocycloheptathiophene derivative3 with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine.3

Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis.3 In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,6 and in Canada a prescription-only oral formulation is available and indicated as an add-on therapy for children with atopic asthma.7 In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various allergic symptoms and disorders,3 including urticaria, mastocytosis, and food allergy.

See full entry for Ketotifen
Accession Number
DBSALT001856
Structure
MOLSDFPDBSMILESInChI
Similar Structures
Synonyms
10H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHEN-10-ONE, 4,9-DIHYDRO-4-(1-METHYL-4-PIPERIDINYLIDENE)-, (E)-2-BUTENEDIOATE (1:1) / 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate (1:1) / HC 20,511 FUMARATE / HC-20511 FUMARATE / Ketotifen (as fumarate) / Ketotifen hydrogen fumarate
External IDs
NSC-757415