Cyproheptadine is a combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. An allergy medication used to treat allergic symptoms itchy eyes, sneezing, and runny nose.
- Mechanism
- Curator reviewed · 1 reference
Cyproheptadine appears to exert its antihistamine and antiserotonin effects by competing with free histamine and serotonin for binding at their respective receptors. Antagonism of serotonin on the appetite center of the hypothalamus may account for cyproheptadine's ability to stimulate the appetite.
- Primary indication
- In the US, prescription cyproheptadine is indicated for the treatment of various allergic symptomatologies - including dermatographia, rhinitis, conjunctivitis, and urticaria - as well as adjunctive therapy in the management of anaphylaxis following treatment with...Curator reviewed · 13 structured indications
- Formula / weight
- C21H21N · 287.3981 g/mol (avg)
- First approval
- Canada, 2010 · United States, 1981
- Code names
- Fl 5967 · HSp 1229
Resolves to
JJCFRYNCJDLXIK-UHFFFAOYSA-NSMILESCN1CCC(CC1)=C1C2=CC=CC=C2C=CC2=CC=CC=C12What you can answer from here — as of September 23, 2026
Which drugs share a target with Cyproheptadine, and which of those have an active Phase 3 trial?
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