Myeloproliferative Disorders (MPD)

Also known as: Myeloproliferative Disorders / Myeloproliferative Disorder / Myeloproliferative Diseases / Myeloproliferative Disease / Myeloproliferative Syndromes / Myeloproliferative Syndrome / Chronic myeloproliferative disease / Myeloproliferative neoplasm / Myeloproliferative disorder NOS / Chronic myeloproliferative disease -RETIRED- / Myeloproliferative disorder (morphologic abnormality) / Disorder myeloproliferative / Myeloproliferative disorder (disorder) / Myeloproliferative disease (morphologic abnormality)

DrugDrug NameDrug Description
DB00261AnagrelideA platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms.
DB00619ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DB00034Interferon alfa-2aA form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
DrugDrug NameTargetType
DB00261AnagrelidecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00261AnagrelideCytochrome P450 1A2enzyme
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBreakpoint cluster region proteintarget
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibP-glycoprotein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00619ImatinibCytochrome P450 2C8enzyme
DB00619ImatinibCanalicular multispecific organic anion transporter 1transporter
DB00619ImatinibMultidrug resistance-associated protein 1transporter
DB00619ImatinibSolute carrier family 22 member 5transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1B3transporter
DB00619ImatinibMultidrug resistance-associated protein 4transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1A2transporter
DB00619ImatinibDiscoidin domain-containing receptor 2target
DB00034Interferon alfa-2aInterferon alpha/beta receptor 1target
DB00034Interferon alfa-2aInterferon alpha/beta receptor 2target
DB00034Interferon alfa-2aCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB00041Aldesleukin1Not Yet Recruiting1
DB00041Aldesleukin1Suspended1
DB00087Alemtuzumab1Terminated1
DB09312Antilymphocyte immunoglobulin (horse)1Completed1
DB00098Antithymocyte immunoglobulin (rabbit)1Completed1
DB01008Busulfan1Completed1
DB00631Clofarabine1Terminated1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Recruiting1
DB00531Cyclophosphamide1Suspended1
DB00531Cyclophosphamide1Terminated1
DB00099Filgrastim1Recruiting1
DB01073Fludarabine1Active Not Recruiting1
DB01073Fludarabine1Completed1
DB01073Fludarabine1Recruiting1
DB01073Fludarabine1Suspended1
DB01073Fludarabine1Terminated1
DB13040Gandotinib1Completed1
DB12047Ganetespib1Completed1
DB16479Inbakicept1Completed1
DB12154Itacitinib1Recruiting1
DB12232KRN-70001Active Not Recruiting1
DB14877Lintuzumab1Completed1
DB01042Melphalan1Active Not Recruiting1
DB01042Melphalan1Recruiting1
DB01042Melphalan1Terminated1
DB00563Methotrexate1Completed1
DB00688Mycophenolate mofetil1Active Not Recruiting1
DB01024Mycophenolic acid1Active Not Recruiting1
DB15721Natural Killer Cell1Not Yet Recruiting1
DB15721Natural Killer Cell1Suspended1
DB12920Pinometostat1Completed1
DB06809Plerixafor1Recruiting1
DB00877Sirolimus1Active Not Recruiting1
DB00864Tacrolimus1Completed1
DB00864Tacrolimus1Recruiting1
DB15310Vactosertib1Suspended1
DB05243XL0191Terminated1
DB00399Zoledronic acid1Recruiting1
DB00087Alemtuzumab1 / 2Terminated1
DB01008Busulfan1 / 2Completed1
DB00531Cyclophosphamide1 / 2Completed1
DB00099Filgrastim1 / 2Terminated1
DB01073Fludarabine1 / 2Completed1
DB01073Fludarabine1 / 2Terminated1
DB01042Melphalan1 / 2Terminated1
DB00563Methotrexate1 / 2Terminated1
DB00959Methylprednisolone1 / 2Terminated1
DB11697Pacritinib1 / 2Completed1
DB17129Pelabresib anhydrous1 / 2Active Not Recruiting1
DB12146Rigosertib1 / 2Completed1
DB04974Rimiducid1 / 2Terminated1
DB08877Ruxolitinib1 / 2Active Not Recruiting1
DB08877Ruxolitinib1 / 2Completed2
DB09143Sonidegib1 / 2Completed1
DB00864Tacrolimus1 / 2Terminated1
DB00041Aldesleukin2Completed1
DB00087Alemtuzumab2Completed2
DB00087Alemtuzumab2Terminated1
DB00437Allopurinol2Completed1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed2
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting1
DB00112Bevacizumab2Completed1
DB01008Busulfan2Completed2
DB01008Busulfan2Terminated1
DB00958Carboplatin2Completed1
DB00631Clofarabine2Completed1
DB00531Cyclophosphamide2Completed4
DB00531Cyclophosphamide2Recruiting1
DB00531Cyclophosphamide2Terminated1
DB00091Cyclosporine2Active Not Recruiting1
DB00091Cyclosporine2Completed3
DB00987Cytarabine2Completed1
DB00997Doxorubicin2Terminated1
DB00773Etoposide2Terminated1
DB17743Fecal microbiota2Recruiting1
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Completed2
DB00099Filgrastim2Terminated2
DB01073Fludarabine2Completed6
DB01073Fludarabine2Recruiting1
DB01073Fludarabine2Terminated4
DB00441Gemcitabine2Completed1
DB12645Givinostat2Completed1
DB00619Imatinib2Unknown Status1
DB05258Interferon alfa2Completed1
DB11633Isavuconazole2Completed1
DB06636Isavuconazonium2Completed1
DB00480Lenalidomide2Completed1
DB00007Leuprolide2Terminated1
DB18369Lyophilized activated platelets2Terminated1
DB01042Melphalan2Completed1
DB01042Melphalan2Recruiting1
DB01042Melphalan2Terminated2
DB00563Methotrexate2Completed3
DB00563Methotrexate2Terminated1
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Completed4
DB00688Mycophenolate mofetil2Terminated1
DB11697Pacritinib2Terminated1
DB00008Peginterferon alfa-2a2Completed1
DB05223Pracinostat2Completed2
DB00635Prednisone2Completed1
DB00635Prednisone2Terminated1
DB00073Rituximab2Terminated1
DB08877Ruxolitinib2Completed2
DB00936Salicylic acid2Terminated1
DB00020Sargramostim2Completed1
DB00877Sirolimus2Completed1
DB00864Tacrolimus2Completed4
DB00864Tacrolimus2Terminated2
DB06273Tocilizumab2Active Not Recruiting1
DB00541Vincristine2Terminated1
DB00673Aprepitant3Recruiting1
DB01008Busulfan3Terminated1
DB00531Cyclophosphamide3Active Not Recruiting1
DB00531Cyclophosphamide3Terminated1
DB00099Filgrastim3Active Not Recruiting1
DB01073Fludarabine3Active Not Recruiting1
DB01073Fludarabine3Terminated1
DB00557Hydroxyzine3Recruiting1
DB12281Luspatercept3Recruiting1
DB00563Methotrexate3Terminated1
DB00688Mycophenolate mofetil3Active Not Recruiting1
DB00864Tacrolimus3Active Not Recruiting1
DB01008Busulfan4Completed1
DB01073Fludarabine4Completed1
DB00945Acetylsalicylic acidNot AvailableCompleted1
DB00087AlemtuzumabNot AvailableTerminated1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB00673AprepitantNot AvailableWithdrawn1
DB01008BusulfanNot AvailableCompleted1
DB09110Coenzyme MNot AvailableTerminated1
DB00531CyclophosphamideNot AvailableTerminated1
DB00987CytarabineNot AvailableTerminated1
DB01073FludarabineNot AvailableCompleted1
DB01005HydroxyureaNot AvailableCompleted1
DB01042MelphalanNot AvailableCompleted1
DB00904OndansetronNot AvailableWithdrawn1