Reaction: Difamilast to 1 product

O-deethylationMajor circulating metaboliteMetabolism of Difamilast

Difamilast is converted to MAP-15485 by Cytochrome P450 3A4.

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Based on in vitro metabolite studies using human liver microsomes, the most abundant metabolite found was MAP-15485.

What you can answer from here — as of March 02, 2026

1EnzymeEach linked to its target card
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2ReferencesThe literature this reaction is curated from
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Which other drugs are metabolised by Cytochrome P450 3A4, and which of those pairings are clinically significant?

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