Cytochrome P450 3A4

BE0002638ProteinHumansCYP3A4

A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). It is acted on by 1178 drugs in DrugBank.

Gene name
CYP3A4
UniProtKB entry
P08684Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
503 residues · 57,343 Da
Also known as
1,4-cineole 2-exo-monooxygenase · 1,8-cineole 2-exo-monooxygenase · 1.14.14.1 · Albendazole monooxygenase (sulfoxide-forming) · Albendazole sulfoxidase

Resolves to

Protein
UniProtP08684UniProt nameCP3A4_HUMAN
Gene
HGNCHGNC:2637NCBI Gene1576GeneCardsCYP3A4
Pharmacology
IUPHAR/GtoPdb1337KEGGhsa:1576
Structure
PDB1TQNPDB1W0EPDB1W0F
Drugs

What you can answer from here — as of September 07, 2019

1,178DrugsApproved to experimental, with action, bond type and pharmacological action
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80Clinical trialsTrials of drugs acting on it, by phase and status
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729Metabolic reactionsDrug transformations it catalyses, substrate to product
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23GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2,676+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 3A4, how selective are they, and which programs against it are still in active trials?

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