Reaction: Fosphenytoin to 1 product

Reaction
Fosphenytoin
DB01320
3-hydroxymethylphenytoin
DBMET03216
Reaction type
hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Yuan H, Li N, Lai Y: Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. Drug Metab Dispos. 2009 Jul;37(7):1443-7. doi: 10.1124/dmd.108.026245. Epub 2009 Apr 16. [Article]
  2. FDA Approved Drug Products: SESQUIENT (fosphenytoin) injection [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Alkaline phosphatase, tissue-nonspecific isozymeNot AvailableNot Availableimplied