Alkaline phosphatase, tissue-nonspecific isozyme

BE0003546ProteinHumansALPL

Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:12162492, PubMed:23688511, PubMed:25982064). It is acted on by 8 drugs in DrugBank.

Gene name
ALPL
UniProtKB entry
P05186Swiss-Prot
Cellular location
Cell membrane
Residues / weight
524 residues · 57,304 Da
Also known as
3.1.3.1 · Alkaline phosphatase liver/bone/kidney isozyme · AP-TNAP · Phosphoamidase · Phosphocreatine phosphatase

Resolves to

Protein
UniProtP05186UniProt namePPBT_HUMAN
Gene
HGNCHGNC:438NCBI Gene249GenBank28738GeneCardsALPL
Pharmacology
KEGGhsa:249
Structure
PDB7YIVPDB7YIWPDB7YIX
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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23GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alkaline phosphatase, tissue-nonspecific isozyme, how selective are they, and which programs against it are still in active trials?

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