Reaction: Dexamethasone to 1 product

Reaction
Dexamethasone
DB01234
6alpha-Hydroxydexamethasone
DBMET01644
Reaction type
Aliphatic hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Gentile DM, Tomlinson ES, Maggs JL, Park BK, Back DJ: Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. J Pharmacol Exp Ther. 1996 Apr;277(1):105-12. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied