Reaction: Ebastine to 2 products

Reaction
Ebastine
DB11742
4-(4-tert-butylphenyl)-4-oxobutanal
DBMET01652
Deslakylebastine
DBMET01651
Reaction type
N-dealkylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Hashizume T, Imaoka S, Mise M, Terauchi Y, Fujii T, Miyazaki H, Kamataki T, Funae Y: Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. J Pharmacol Exp Ther. 2002 Jan;300(1):298-304. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied