Reaction: vemurafenib intermediary metabolite to 1 product

Reaction
vemurafenib intermediary metabolite
DBMET01854
    secondary metabolite of vemurafenib alternative
    DBMET01856
    Reaction type
    Dehalogenation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Goldinger SM, Rinderknecht J, Dummer R, Kuhn FP, Yang KH, Lee L, Ayala RC, Racha J, Geng W, Moore D, Liu M, Joe AK, Bazan SP, Grippo JF: A single-dose mass balance and metabolite-profiling study of vemurafenib in patients with metastatic melanoma. Pharmacol Res Perspect. 2015 Mar;3(2):e00113. doi: 10.1002/prp2.113. [Article]
    Comments
    Not Available
    Enzymes
    Not Available