Reaction: U7 semaglutide to 1 product

Reaction
U7 semaglutide
DBMET01886
U6 semaglutide
DBMET01887
Reaction type
hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Jensen L, Helleberg H, Roffel A, van Lier JJ, Bjornsdottir I, Pedersen PJ, Rowe E, Derving Karsbol J, Pedersen ML: Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41. doi: 10.1016/j.ejps.2017.03.020. Epub 2017 Mar 16. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
NeprilysinNot AvailableNot Availableconfirmed