Neprilysin

BE0000266ProteinHumansMME

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:6208535, PubMed:6349683, PubMed:8168535). It is acted on by 27 drugs in DrugBank.

Gene name
MME
UniProtKB entry
P08473Swiss-Prot
Cellular location
Cell membrane
Residues / weight
750 residues · 85,513 Da
Also known as
3.4.24.11 · Atriopeptidase · CALLA · Common acute lymphocytic leukemia antigen · Enkephalinase

Resolves to

Protein
UniProtP08473UniProt nameNEP_HUMAN
Gene
HGNCHGNC:7154NCBI Gene4311GenBank34758GeneCardsMME
Pharmacology
IUPHAR/GtoPdb1611KEGGhsa:4311
Structure
PDB1DMTPDB1R1HPDB1R1I
Drugs

What you can answer from here — as of September 07, 2019

27DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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28GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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81+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neprilysin, how selective are they, and which programs against it are still in active trials?

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