Reaction: Ertugliflozin M2 metabolite to 2 products

Reaction
Ertugliflozin M2 metabolite
DBMET01906
Ertugliflozin M5a metabolite
DBMET01907
Ertugliflozin M5b metabolite
DBMET01908
Reaction type
glucuronidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Miao Z, Nucci G, Amin N, Sharma R, Mascitti V, Tugnait M, Vaz AD, Callegari E, Kalgutkar AS: Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551. Epub 2012 Nov 20. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1A9Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 2B7Not AvailableNot Availableconfirmed