UDP-glucuronosyltransferase 1A9

BE0003538ProteinHumansUGT1A9

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:15472229,... It is acted on by 99 drugs in DrugBank.

Gene name
UGT1A9
UniProtKB entry
O60656Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
530 residues · 59,940 Da
Also known as
2.4.1.17 · GNT1 · lugP4 · UDP-glucuronosyltransferase 1-9 · UDP-glucuronosyltransferase 1-I

Resolves to

Protein
UniProtO60656UniProt nameUD19_HUMAN
Gene
HGNCHGNC:12541NCBI Gene54600GenBank7690346GeneCardsUGT1A9
Pharmacology
KEGGhsa:54600
Drugs

What you can answer from here — as of September 03, 2024

99DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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76Metabolic reactionsDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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152+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A9, how selective are they, and which programs against it are still in active trials?

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