Reaction: Ibrutinib to 1 product

Reaction
Ibrutinib
DB09053
    PCI-45752 (M34)
    DBMET02027
    Reaction type
    dehydrogenation; hydroxylation; reduction
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    active
    References
    1. Scheers E, Leclercq L, de Jong J, Bode N, Bockx M, Laenen A, Cuyckens F, Skee D, Murphy J, Sukbuntherng J, Mannens G: Absorption, metabolism, and excretion of oral (1)(4)C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97. doi: 10.1124/dmd.114.060061. Epub 2014 Dec 8. [Article]
    Comments
    Not Available
    Enzymes
    Not Available