Reaction: Lisdexamfetamine to 2 products

Reaction
Lisdexamfetamine
DB01255
    Dextroamphetamine
    DB01576
    Lysine
    DB00123
    Reaction type
    hydrolysis
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    active
    References
    1. Goodman DW: Lisdexamfetamine dimesylate (vyvanse), a prodrug stimulant for attention-deficit/hyperactivity disorder. P T. 2010 May;35(5):273-87. [Article]
    2. Krishnan SM, Pennick M, Stark JG: Metabolism, distribution and elimination of lisdexamfetamine dimesylate: open-label, single-centre, phase I study in healthy adult volunteers. Clin Drug Investig. 2008;28(12):745-55. doi: 10.2165/0044011-200828120-00002. [Article]
    3. FDA Approved Drug Products: VYVANSE (lisdexamfetamine dimesylate) capsules and chewable tablets, for oral use, CII (January 2022) [Link]
    Comments
    Not Available
    Enzymes
    Not Available