Dextroamphetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Dextroamphetamine is the dextrorotatory enantiomer of amphetamine.
- Mechanism
- Curator reviewed · 2 references
The exact mechanism of amphetamines as a class is not known. Dextroamphetamine acts by preventing reuptake, increasing release, and stimulating reverse-transport of dopamine in synaptic clefts in the striatum. Newer evidence shows amphetamines may also alter the number of dopamine transporters in synaptic clefts.
- Primary indication
- Dextroamphetamine is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.Curator reviewed · 5 structured indications
- Formula / weight
- C9H13N · 135.2062 g/mol (avg)
- First approval
- Canada, 2015 · United States, 1975
- Also known as
- (S)-amphetamine · d-amphetamine · Dexamfetamine · Dexamphetamine
- Code names
- NSC-73713
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
KWTSXDURSIMDCE-QMMMGPOBSA-NSMILESC[C@H](N)CC1=CC=CC=C1Transporters
What you can answer from here — as of September 26, 2026
6Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
1TransporterSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Dextroamphetamine, and which of those have an active Phase 3 trial?
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