Reaction: Prucalopride to 1 product

Reaction
Prucalopride
DB06480
Desmethyl prucalopride
DBMET02197
Reaction type
demethylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Buiter HJ, Windhorst AD, Huisman MC, De Maeyer JH, Schuurkes JA, Lammertsma AA, Leysen JE: Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor. EJNMMI Res. 2013 Apr 4;3(1):24. doi: 10.1186/2191-219X-3-24. [Article]
  2. EMA reports [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed