Reaction: Methylphenidate to 1 product
- Reaction
- Reaction type
- esterase hydrolysis
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- inactive
- References
- Sun Z, Murry DJ, Sanghani SP, Davis WI, Kedishvili NY, Zou Q, Hurley TD, Bosron WF: Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76. doi: 10.1124/jpet.104.067116. Epub 2004 Apr 13. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Carboxylesterase Not Available Not Available confirmed