Reaction: Palbociclib to 2 products

Reaction
Palbociclib
DB09073
Palbociclib M14
DBMET02372
Palbociclib M4
DBMET02371
Reaction type
N-dealkylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Chavan BB, Tiwari S, G S, Nimbalkar RD, Garg P, R S, Talluri MVNK: In vitro and in vivo metabolic investigation of the Palbociclib by UHPLC-Q-TOF/MS/MS and in silico toxicity studies of its metabolites. J Pharm Biomed Anal. 2018 Aug 5;157:59-74. doi: 10.1016/j.jpba.2018.05.008. Epub 2018 May 16. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied