Reaction: Fluconazole to 1 product

Reaction
Reaction type
oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Brammer KW, Coakley AJ, Jezequel SG, Tarbit MH: The disposition and metabolism of [14C]fluconazole in humans. Drug Metab Dispos. 1991 Jul-Aug;19(4):764-7. [Article]
  2. Locuson CW, Hutzler JM, Tracy TS: Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common. Drug Metab Dispos. 2007 Apr;35(4):614-22. doi: 10.1124/dmd.106.012609. Epub 2007 Jan 24. [Article]
Comments
Sources differ regarding the oxidation site of fluconazole n-oxide. It has been suggested that oxidation may be performed by CYP3A4.
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied