Reaction: Salmeterol to 1 product

Reaction
Salmeterol
DB00938
alpha-hydroxysalmeterol
DBMET00386
Reaction type
hydroxylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Cazzola M, Testi R, Matera MG: Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet. 2002;41(1):19-30. doi: 10.2165/00003088-200241010-00003. [Article]
  2. Zhang M, Fawcett JP, Shaw JP: Rapid chiral high-performance liquid chromatographic assay for salmeterol and alpha-hydroxysalmeterol. Application to in vitro metabolism studies. J Chromatogr B Biomed Sci Appl. 1999 Jun 11;729(1-2):225-30. doi: 10.1016/s0378-4347(99)00156-5. [Article]
  3. FDA Approved Drug Products: Wixela Inhub Fluticasone and Salmeterol Inhalation Powder [Link]
  4. FDA Approved Drug Products: Serevent Diskus Salmeterol Inhalation Powder [Link]
  5. FDA Approved Drug Products: Airduo Respiclick Fluticasone and Salmeterol Inhalation Powder [Link]
  6. FDA Approved Drug Products: Advair HFA Fluticasone and Salmeterol Inhalation Aerosol [Link]
  7. FDA Approved Drug Products: Advair Diskus Fluticasone and Salmeterol Inhalation Powder [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed