Reaction: Pretomanid to 1 product

Reaction
Pretomanid
DB05154
Des-nitroso derivative, Pretomanid
DBMET02737
Reaction type
reduction
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Thompson AM, Bonnet M, Lee HH, Franzblau SG, Wan B, Wong GS, Cooper CB, Denny WA: Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. ACS Med Chem Lett. 2017 Nov 13;8(12):1275-1280. doi: 10.1021/acsmedchemlett.7b00356. eCollection 2017 Dec 14. [Article]
  2. Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824) [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Deazaflavin-dependent nitroreductaseNot AvailableNot Availableimplied