Reaction: Pretomanid to 1 product
- Reaction
- Reaction type
- reduction
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Thompson AM, Bonnet M, Lee HH, Franzblau SG, Wan B, Wong GS, Cooper CB, Denny WA: Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. ACS Med Chem Lett. 2017 Nov 13;8(12):1275-1280. doi: 10.1021/acsmedchemlett.7b00356. eCollection 2017 Dec 14. [Article]
- Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824) [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Deazaflavin-dependent nitroreductase Not Available Not Available implied