Reaction: Anastrozole to 1 product
N-dealkylationMetabolism of Anastrozole
Anastrozole is converted to Triazole.
- Reaction
- Direction
- Activity
- inactive
- Comments
- Triazole (a product of N-dealkylation of anastrozole) has long been considered a major circulating metabolite as per anastrozole's label. Follow-up studies on anastrozole metabolism (Kamdem, et. al. 2010) have failed to detect it in plasma, so the importance of triazole as a metabolite, as well as the process through which it is created, are unclear.
What you can answer from here — as of September 30, 2019
Which metabolites of Anastrozole are active, and how do they change its interactions?
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