Reaction: Diroximel fumarate to 4 products

Reaction
Diroximel fumarate
DB14783
2-hydroxyethyl succinimide
DBMET02865
Methanol
DBMET00536
Monomethyl fumarate
DB14219
RDC-8439
DBMET02866
Reaction type
esterase hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Palte MJ, Wehr A, Tawa M, Perkin K, Leigh-Pemberton R, Hanna J, Miller C, Penner N: Improving the Gastrointestinal Tolerability of Fumaric Acid Esters: Early Findings on Gastrointestinal Events with Diroximel Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis from the Phase 3, Open-Label EVOLVE-MS-1 Study. Adv Ther. 2019 Nov;36(11):3154-3165. doi: 10.1007/s12325-019-01085-3. Epub 2019 Sep 19. [Article]
  2. Vumerity FDA label [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Liver esterasesNot AvailableNot Availableconfirmed