Reaction: Decitabine to 1 product

Reaction
Decitabine
DB01262
5-aza-2'-deoxycytidine-monophosphate
DBMET03187
Reaction type
phosphorylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Momparler RL, Derse D: Kinetics of phosphorylation of 5-aza-2'-deoxyycytidine by deoxycytidine kinase. Biochem Pharmacol. 1979 Apr 15;28(8):1443-4. doi: 10.1016/0006-2952(79)90454-4. [Article]
  2. Ueda K, Masuda A, Fukuda M, Tanaka S, Hosokawa M, Iwakawa S: Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells. Drug Metab Pharmacokinet. 2017 Dec;32(6):301-310. doi: 10.1016/j.dmpk.2017.10.001. Epub 2017 Oct 10. [Article]
  3. Oki Y, Aoki E, Issa JP: Decitabine--bedside to bench. Crit Rev Oncol Hematol. 2007 Feb;61(2):140-52. Epub 2006 Oct 4. [Article]
  4. Seelan RS, Mukhopadhyay P, Pisano MM, Greene RM: Effects of 5-Aza-2'-deoxycytidine (decitabine) on gene expression. Drug Metab Rev. 2018 May;50(2):193-207. doi: 10.1080/03602532.2018.1437446. Epub 2018 Feb 18. [Article]
  5. Diesch J, Zwick A, Garz AK, Palau A, Buschbeck M, Gotze KS: A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers. Clin Epigenetics. 2016 Jun 21;8:71. doi: 10.1186/s13148-016-0237-y. eCollection 2016. [Article]
  6. Momparler RL, Rossi M, Bouchard J, Vaccaro C, Momparler LF, Bartolucci S: Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase. Mol Pharmacol. 1984 May;25(3):436-40. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Deoxycytidine kinaseNot AvailableNot Availableconfirmed