Deoxycytidine kinase

BE0002804ProteinHumansDCK

Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). It is acted on by 17 drugs in DrugBank.

Gene name
DCK
UniProtKB entry
P27707Swiss-Prot
Cellular location
Nucleus
Residues / weight
260 residues · 30,518 Da
Also known as
2.7.1.74 · dCK · Deoxyadenosine kinase · Deoxyguanosine kinase

Resolves to

Protein
UniProtP27707UniProt nameDCK_HUMAN
Gene
HGNCHGNC:2704NCBI Gene1633GeneCardsDCK
Pharmacology
KEGGhsa:1633
Structure
PDB1P5ZPDB1P60PDB1P61
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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6Metabolic reactionsDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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69+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Deoxycytidine kinase, how selective are they, and which programs against it are still in active trials?

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