Reaction: Decitabine to 1 product

Reaction
Decitabine
DB01262
5-aza-2'-deoxyuridine
DBMET03190
Reaction type
deamination
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Chabot GG, Bouchard J, Momparler RL: Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside. Biochem Pharmacol. 1983 Apr 1;32(7):1327-8. doi: 10.1016/0006-2952(83)90293-9. [Article]
  2. Seelan RS, Mukhopadhyay P, Pisano MM, Greene RM: Effects of 5-Aza-2'-deoxycytidine (decitabine) on gene expression. Drug Metab Rev. 2018 May;50(2):193-207. doi: 10.1080/03602532.2018.1437446. Epub 2018 Feb 18. [Article]
  3. Diesch J, Zwick A, Garz AK, Palau A, Buschbeck M, Gotze KS: A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers. Clin Epigenetics. 2016 Jun 21;8:71. doi: 10.1186/s13148-016-0237-y. eCollection 2016. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytidine deaminaseNot AvailableNot Availableconfirmed