Reaction: Diltiazem to 1 product

Reaction
Diltiazem
DB00343
N-monodesmethyl diltiazem
DBMET03220
Reaction type
N-demethylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Yeung PK, Prescott C, Haddad C, Montague TJ, McGregor C, Quilliam MA, Xei M, Li R, Farmer P, Klassen GA: Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose. Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed