Reaction: Dabigatran etexilate to 1 product

Reaction
Dabigatran etexilate
DB06695
BIBR0951/M2
DBMET03376
Reaction type
hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W: The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos. 2008 Feb;36(2):386-99. doi: 10.1124/dmd.107.019083. Epub 2007 Nov 15. [Article]
  2. Hu ZY, Parker RB, Herring VL, Laizure SC: Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704. doi: 10.1007/s00216-012-6576-4. Epub 2012 Dec 14. [Article]
  3. Laizure SC, Parker RB, Herring VL, Hu ZY: Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis. Drug Metab Dispos. 2014 Feb;42(2):201-6. doi: 10.1124/dmd.113.054353. Epub 2013 Nov 8. [Article]
  4. FDA Approved Drug Products: PRADAXA (dabigatran) oral pellets [Link]
  5. FDA Approved Drug Products: PRADAXA (dabigatran) oral capsules [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cocaine esteraseNot AvailableNot Availableimplied