Cocaine esterase

BE0004712ProteinHumansCES2

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). It is acted on by 15 drugs in DrugBank.

Gene name
CES2
UniProtKB entry
O00748Swiss-Prot
Cellular location
Endoplasmic reticulum lumen
Residues / weight
559 residues · 61,806 Da
Also known as
3.1.1.84 · Carboxylesterase 2 · CE-2 · hCE-2 · ICE

Resolves to

Protein
UniProtO00748UniProt nameEST2_HUMAN
Gene
HGNCHGNC:1864NCBI Gene8824GeneCardsCES2
Pharmacology
IUPHAR/GtoPdb3298KEGGhsa:8824
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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7Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cocaine esterase, how selective are they, and which programs against it are still in active trials?

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