Reaction: Macitentan to 1 product

Reaction
Macitentan
DB08932
    M3
    DBMET03420
    Reaction type
    hydrolysis
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    inactive
    References
    1. Sidharta PN, Treiber A, Dingemanse J: Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan. Clin Pharmacokinet. 2015 May;54(5):457-71. doi: 10.1007/s40262-015-0255-5. [Article]
    2. FDA Approved Drug Products: OPSUMIT (macitentan) tablets [Link]
    Comments
    Not Available
    Enzymes
    Not Available