Reaction: Pacritinib to 1 product

Reaction
Pacritinib
DB11697
Pacritinib M2 metabolite
DBMET03436
Reaction type
O-dealkylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Jayaraman R, Pasha MK, Williams A, Goh KC, Ethirajulu K: Metabolism and Disposition of Pacritinib (SB1518), an Orally Active Janus Kinase 2 Inhibitor in Preclinical Species and Humans. Drug Metab Lett. 2015;9(1):28-47. doi: 10.2174/1872312809666150119105250. [Article]
  2. FDA Approved Drug Products: Vonjo (pacritinib) capsules for oral use [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed