Reaction: Bupropion to 1 product
- Reaction
- Reaction type
- Aromatic hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Chen Y, Liu HF, Liu L, Nguyen K, Jones EB, Fretland AJ: The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19. Xenobiotica. 2010 Aug;40(8):536-46. doi: 10.3109/00498254.2010.492880. [Article]
- Sager JE, Choiniere JR, Chang J, Stephenson-Famy A, Nelson WL, Isoherranen N: Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans. ACS Med Chem Lett. 2016 Jun 17;7(8):791-6. doi: 10.1021/acsmedchemlett.6b00189. eCollection 2016 Aug 11. [Article]
- Connarn JN, Zhang X, Babiskin A, Sun D: Metabolism of bupropion by carbonyl reductases in liver and intestine. Drug Metab Dispos. 2015 Jul;43(7):1019-27. doi: 10.1124/dmd.115.063107. Epub 2015 Apr 22. [Article]
- Costa R, Oliveira NG, Dinis-Oliveira RJ: Pharmacokinetic and pharmacodynamic of bupropion: integrative overview of relevant clinical and forensic aspects. Drug Metab Rev. 2019 Aug;51(3):293-313. doi: 10.1080/03602532.2019.1620763. Epub 2019 Jun 14. [Article]
- Gufford BT, Lu JB, Metzger IF, Jones DR, Desta Z: Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo. Drug Metab Dispos. 2016 Apr;44(4):544-53. doi: 10.1124/dmd.115.068908. Epub 2016 Jan 22. [Article]
- Dash RP, Rais R, Srinivas NR: Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion. Xenobiotica. 2018 Sep;48(9):945-957. doi: 10.1080/00498254.2017.1376765. Epub 2017 Oct 13. [Article]
- Petsalo A, Turpeinen M, Tolonen A: Identification of bupropion urinary metabolites by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(16):2547-54. doi: 10.1002/rcm.3117. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C19 Not Available Not Available confirmed
