Cytochrome P450 2C19

BE0003536ProteinHumansCYP2C19

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). It is acted on by 383 drugs in DrugBank.

Gene name
CYP2C19
UniProtKB entry
P33261Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
490 residues · 55,945 Da
Also known as
(R)-limonene 6-monooxygenase · (S)-limonene 6-monooxygenase · (S)-limonene 7-monooxygenase · 1.14.14.1 · CYPIIC17

Resolves to

Protein
UniProtP33261UniProt nameCP2CJ_HUMAN
Gene
HGNCHGNC:2621NCBI Gene1557GenBank181344GeneCardsCYP2C19
Pharmacology
IUPHAR/GtoPdb1328KEGGhsa:1557
Structure
PDB4GQS
Drugs

What you can answer from here — as of September 07, 2019

383DrugsApproved to experimental, with action, bond type and pharmacological action
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32Clinical trialsTrials of drugs acting on it, by phase and status
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231Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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859+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2C19, how selective are they, and which programs against it are still in active trials?

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