Reaction: Pirfenidone to 1 product

Reaction
Reaction type
5-hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Togami K, Kanehira Y, Tada H: Possible involvement of pirfenidone metabolites in the antifibrotic action of a therapy for idiopathic pulmonary fibrosis. Biol Pharm Bull. 2013;36(10):1525-7. doi: 10.1248/bpb.b13-00452. [Article]
  2. Zhang Y, Sato R, Fukami T, Nakano M, Nakajima M: Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver. Xenobiotica. 2021 Dec;51(12):1352-1359. doi: 10.1080/00498254.2021.2007553. Epub 2021 Nov 30. [Article]
  3. FDA Approved Drug Products: Esbriet (pirfenidone) for oral use [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1A2Not AvailableNot Availableconfirmed